How can I turn a list of words in a text file into a regex to filter out?

I'm trying to filter out some text for certain keywords that are found in a text file. I was thinking about just parsing the file line by line, take each word and then merge them together with a pipe "|" then using that string inside re.sub.

Any better开发者_运维知识库 more efficient ideas are welcome.

Something like this without regexp?

import string
keyset = set(open('keywords.txt').read().splitlines())
for lineno,line in  enumerate(open('textfile.txt')):
    result = [kw
              for kw in keyset
              for w in line.split()
              if kw in w and w.strip(string.punctuation) == kw]
    if result:
        print "%5s (%s): %s" % (lineno,', '.join(result), line),

Something like the following?

import re

with file('keywords.txt', 'r') as k:
    kwords = sorted(k.read().strip().split(), lambda x: (len(x), x))
searchstring = r'\s?\b(' + '|'.join(kwords) + r')\b'
with file('textfile.txt', 'r') as t:
    text = t.read()
newtext, _ = re.subn(searchstring, '', text).lstrip()