Alternatives to JUpload for very large (> 2GB) files

Our customers need to upload very large files (around 10GB or so) to our web-service. Ignoring any server side complexities, what options exist for the client side? JUpload seems to be the most common, but it's file selector is very unfriendly looking. Our clients would be happy to install a browser extension, so it doesn't need to be limited to Java, and something that uses the native OS file selector would be preferred. Browsers used by customers include the usual (IE, Firefox, Safari and Chrome), but we may be able to limit clients to a particular browser, so something that is not cross-browser may be acceptable, but is certainly not preferr开发者_运维知识库ed.

We use https://transloadit.com/ for this purpose, but some web browsers may not support larger than 2GB files.