Isolate an emacs frame

I normally open a new emacs frame when context switching to a different project. Unfortunately, find-file history is shared between frames. Is it possible to open a new frame which is 'blank', i.e. doesn'开发者_如何学Pythont remember any of the state from any other frame?

find-file does not make distinctions between frames, you could launch a new emacs if you want to separate your environments :

M-& emacs RET

NB : emacs should be in your path.