Javascript Regex - Every sign but not XX

i must convert a string (user generated) to a regex rule.

My problem is that i must say,

replace every sign but not a-b, 0-9, minus, dot and comma

I hope somebody can help.

HTML

<div id="d1" class="开发者_开发知识库line1"></div>

JS

$(function() {

    new_regex_rule = 'hello,bl.com,dkd-dkd.com,blub,blib,satssan kommt';

    // new_regex_rule = new_regex_rule.replace(/[a-z][0-9][-.]/gi,'');

    $('#d1').append('<hr />'+new_regex_rule+'<hr />');  

    if(new_regex_rule.match(/\s/)){ new_regex_rule = new_regex_rule.replace(/\s/,'\\s'); }
    if(new_regex_rule.match(/,/)){ new_regex_rule = new_regex_rule.replace(/\,/,'|'); }

    $('#d1').append('<hr />'+new_regex_rule+'<hr />');  
});

working example

http://www.jsfiddle.net/V9Euk/517/

Thanks in advance! Peter

EDIT: Or is ist maybe possible to use the string as regex rule as it is?

this one replaces every sign but not a-b, 0-9, minus, dot and comma (case sensitive)

var regex = /[^a-z0-9.,]/g
alert("cAspar.@hotmail.com.replace?".replace(regex,"X"));