Changing the button BackColor Property

I want to change the backcolor of the Button when the but开发者_StackOverflowtonFlatStyle property is set to System.is it possible to do it?

No.
When the FlatStyle property i set to System the appearance of the control is determined by the user's operating system.

For more info see: http://msdn.microsoft.com/en-us/library/system.windows.forms.flatstyle.aspx