Can be URLs of Ajax request be made without hashes?

I've configured mod_rewrite on the site, and all URLs look like site.com/smth/else

In profile section of the site I want to make ajax navigation, so URLs will be changed with hashes: site.com/profile#smth

Can I make these a开发者_Python百科jax URLs look like others (with slashes but not hashes) - is it possible?

It is not possible. The only possible way to change current url without reloading of the whole page - is to change its anchor part.