Visual Studio: Why sometimes "Start Without Debugging" much slower than "Start Debugging"?

I'm usin开发者_C百科g Visual Studio 2010, C#, WPF. I noticed in some of my projects, "Start Without Debugging" is much more slower than "Start Debugging", maybe 50 times slower.

When "Start Debugging", everything is normal, UI is smooth and responsive. But when "Start Without Debugging", every operation freezes UI for 30~60 seconds.

What are the common causes of this problem? Thanks.

(sorry, I can't upload my projects)

Do you have the problem in Release builds as well?

Are you running antivirus?

Sorry, but I'm not sure we can diagnose your problem without more information.