Two factor authentication for Microsoft outlook

Is there any way to provide two factor authentication for Microsoft Outlook client.开发者_运维知识库 It may use ISA server or any other. Basically 2-factor authentication is possible for OWA but I haveb't been able to find a way to implement it for Microsoft Outlook.

In order for that to work, you would have to change the authentication method in Exchange. This is easy to do in packages like postfix a la:http://www.wikidsystems.com/support/wikid-support-center/how-to/how-to-configure-webmail-for-wikid-strong-authentication/, however, I bet it would a lot harder for Exchange.