Force a new start of "Cassini" when I start debugging a new instance of my web application

In our ASP.NET application we perform some initializations upon the Application Start event.

When the applicat开发者_StackOverflowion is started in visual Studio 2010 with 'Debug->Start new instance' the ASP.NET Development server does not start new, and my Application's Start event is not fired.

My workaround is to manually stop the development server - is there a setting to force this automatically?

I think setting Project properties > Web > Enable Edit and Continue forces Cassini to restart when debugging is started.