Problem authentication django

I have the problem of authentication django.

The first time after restarting the server everything works fine, but after some time of work (several hours) authentication will not work: when you log into the admin area gives "It seems that your browser is not configured to accept cookies. Please enable cookies, reload the page and try again. " Cookies are enabl开发者_如何学编程ed, of course. After server restart everything worked again (some time).

Tried and Apache + mod_wsgi and nginx + FastCGI: a problem everywhere. Locally on a development server (runserver) everything works fine. What may be the problem?

Here is a discussion about how the cookie problem in admin is solved, its in mod_python though but it will give you an idea.